To further determine whether FAM225B mediates malignant phenotypes of NPC cells through a CCND2-dependent manner, pcDNA-CCND2 or pcDNA-NC vector was co-transfected into CNE-2 and SUNE-1 cells with si-FAM225B or si-NC (Figure 6A and 6B). The gene discussed is CCND2; the disease is nasopharyngeal carcinoma.