Studies in HCT116 colon cancer cells demonstrate that theinhibition of the CREBBP/EP300 bromodomain results in the downregulationof c-Myc, which is consistent with the hypothesis that (−)-OXFBD05(2) is selectively inhibiting the CREBBP/EP300 bromodomainsin this cell line. The gene discussed is CREBBP; the disease is malignant colon neoplasm.