Scutellarin (SCU) enhanced inhibition of 125I‐induced proliferation, promoted 125I‐induced apoptosis, and boosted 125I‐induced tumor inhibition in vivo in non‐small cell lung cancer (NSCLC) cells, as well as enhanced downregulation of the 125I‐induced AKT/mTOR pathway. This evidence concerns the gene MTOR and lung cancer.