PVs in some genes involved in CPS previously reported to be associated with PDAC including STK11, MSH2 MSH6, MLH1, APC and PMS2 in hereditary colorectal cancer, unexpectedly, had relatively low prevalences (<1%) with only APC reaching a cumulative frequency of >1% for any group of patients (FPC). This evidence concerns the gene PMS2 and familial colorectal cancer.