Using a lineage labeling method to track dissemination in a spontaneous metastasis model of pancreatic cancer (Aiello et al. 2016), they found that epithelial markers such as Ecad and Claudin-7 increased as disseminated cells evolved from isolated tumor cells to micrometastic and macrometastatic clusters, while mesenchymal markers decreased. This evidence concerns the gene CLDN7 and familial pancreatic carcinoma.