It should be noted that CD3+/CD8+ TILs were lack in Pt204’s primary tumor in which genes related to cytolytic markers, IFN-γ signature and chemokines were universally low expressed, whereas both infiltration levels of CD3/CD8 positive T cells and gene expression of those pro-inflammatory pathways or markers were significantly elevated in metastases after post-operative systemic therapy. The gene discussed is IFNG; the disease is neoplasm.