A recent clinical trial in patients with schizophrenia found that a 5-HT1A receptor agonist, SEP-363856, was more effective than placebo at reducing psychosis symptom scores after 4 weeks of treatment, highlighting the potential relevance of serotonergic pathways to the treatment of psychosis (Koblan et al. 2020). The gene discussed is HTR1A; the disease is psychotic disorder.