In this study, we carried out the functional rescue assays, and found that miR-877-3p inhibition attenuated the suppressive actions of linc00941 knockdown in the ESCC cell proliferation and metastasis, suggesting that linc00941 siRNA exerts tumor suppressive effects on ESCC at least via miR-877-3p. This evidence concerns the gene LINC00941 and neoplasm.