One example is an association between dominantly inherited complex immune disorders and gain‐of‐function mutations in PLCγ2, such as deletions in the PLCG2‐associated antibody deficiency and immune dysregulation (PLAID) disorder that occur in the cSH2 autoinhibitory domain (Ombrello et al, 2012). The gene discussed is PLCG2; the disease is agammaglobulinemia.