The percentages of PD-L1+monocytes and PD-L1 MFI were higher in NSCLC patients with OSA than in the NSCLC patients without OSA (PD-L1+monocytes 86.00 (75.30%, 97.70%) vs. 95.30% (82.10%, 99.45%), P=0.017, Fig. 2c; PD-L1 MFI 2025 (1569, 2246) vs. 2753 (2255, 3819), P<0.001, Fig. 2b). Here, CD274 is linked to obstructive sleep apnea syndrome.