In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial of the GLP-1-receptor agonist liraglutide, more biliary cancers were observed among those receiving active treatment vs placebo (six vs two events), with all but one event in the liraglutide group being cholangiocarcinomas [11]. Here, GLP1R is linked to diabetes mellitus.