However, treatment with either oHSV-1 or FEC + oHSV-1 shows a markedly different gene signature, with both oHSV-1 and FEC + oHSV-1 treatments upregulating many genes associated with the B-cell lineage (Fig. 5D, Supplementary Data 1), including Ifitm1, Il1b, CD24a, CXCL12, FGF7, and Nrg1. A signature comprising the top 29 upregulated genes from this analysis was surveyed across a large dataset of publicly available breast cancer patient data for prognostic relevance34. The gene discussed is NRG1; the disease is breast cancer.