In BRCA2, pathogenic variants in different PCa cohorts, TCGA, and ClinVar datasets show a peak over the central flexible region including BRCA2 repeats (Pfam code: PF00634), that constitute the interaction region with RAD51 (IntAct accessions: EBI-79792 and EBI-15557721). This evidence concerns the gene BRCA2 and posterior cortical atrophy.