In BRCA1, the pathogenic germline variants from ClinVar show a uniform distribution, but in different cohorts of PCa they accumulate over a flexible region connecting a RING type Zinc finger (zf-C3HC4; Pfam code: PF00097) and the serine-rich region associated with BRCT (BRCT_assoc; Pfam code: PF12820) N-terminal domains. Here, BRCA1 is linked to posterior cortical atrophy.