PTEN and metastatic neoplasm: On the other hand, Pfam domains affected by somatic variants identified in metastatic tumours also included the known tumour suppressor genes P53 and PTEN: P53 DNA-binding (Pfam code: PF00870, 408 variants), PTEN-C2 (Pfam code: PF10409, 44 variants) and P53 tetramer (Pfam code: PF07710, 27 variants).