Following RDN, a decrease in plasma renin activity has been shown in a rabbit model of hypertension secondary to chronic kidney disease14 and a decrease in renal renin is seen in a mouse model of neurogenic hypertension13, while in the spontaneously hypertensive rat model of essential hypertension, total RDN had no effect plasma renin activity or kidney renin content46. The gene discussed is REN; the disease is essential hypertension.