The mechanism responsible for the suppressed systemic renin in our model may well be a consequence of the severe hypertension (~ 230 mmHg vs ~ 150 mmHg in the pck rat at a similar age), given that pressure dependent feedback on juxtaglomerular renin secretion through this classical pathway is linked to increased systemic and renal reperfusion pressures41. Here, REN is linked to Hypertension.