In this report, we evaluated the long-term in vitro effects of norepinephrine (NE) treatment using a model of isogenic cells postulated to be the precursors of ovarian cancer—the fallopian tube epithelial cells (iFTSEC283) and ovarian surface epithelial cells (iOSE11)15–18, which share tissue-specific signatures and transcription regulatory architecture28, and isogenic cell lines with oncogenic dominant-negative mutant p53 p.R175H to assess the extent to which p53 status influences transcriptional responses after long-term exposure to NE. Here, TP53 is linked to ovarian cancer.