One of the most strongly upregulated genes, prostaglandin E synthase (PTGES) (log2FoldChange = 6.67), was shown to contribute to ovarian carcinoma by increasing metastasis through prostaglandin E2 (PGE2) synthesis via ADRB2-Nf-kB axis7. This evidence concerns the gene NFKB1 and ovarian carcinoma.