These genes include downregulation of intercellular tight junction component desmoplakin (DSP), collagen interacting proteoglycan biglycan (BGN), extracellular matrix protein ABI3 binding protein (ABI3BP), and integrin binding protein periostin (POSTN); and upregulation of extracellular matrix-degrading urokinase PLAU and cell adhesion molecule MCAM. Additionally, in response to chronic NE treatment, iFTSEC283p53R175H cells also upregulated a stress-activated p38 isoform, MAPK13, which has been shown to be positively associated with tumor initiation 43. Here, POSTN is linked to neoplasm.