Finally, when stratifying the SARS-CoV-2 positive TCRs by open reading frame (ORF) and by CD8 or CD4 specificity, we noted in both cohorts that certain areas of the viral genome had increased likelihood of being targeted in severe infection as well as there also being differences in the CD8 versus CD4 response across multiple ORFs (Fig. 2f). The gene discussed is CD8A; the disease is infection.