Rapidly evolving significant biomedical evidence that links TPC2 to cancer11 and the highly reported genetic variations6 at the global level necessitate investigating the association between TPCN2 polymorphisms and cancer in humans to provide insight into its potential applications as a biomarker in terms of the definition of tumour types, susceptibility, prognosis, and cancer outcomes. The gene discussed is TPCN2; the disease is neoplasm.