TP53 and mesothelioma: We observed significant reduction of P2RX4 expression in patients with mesothelioma stratified by presence/absence of a TP53 mutation (P value, 3.569600e−01) using the UALCAN database31 and infer that the increase of mesothelioma risk associated with this genetic mutation can be attributed to the reduction in P2RX4 activity.