P2RX4 and Familial prostate cancer: The recently identified biological significance of P2RX4 in prostate human biology by He et al.17 warrants further investigation in humans to discover the clinical genomic relevance of P2RX4 variation and prostate cancer at the phenotypic level, which is reflected in changes in expression or activity at the molecular level that have contributed to understanding P2RX4 roles in the pathophysiology of prostate cancer and their diagnostic and therapeutic applications.