Three key pathways were negatively enriched in CtBP1-KD cells, including epithelial to mesenchymal transition in colorectal cancer, MAPK signaling pathway, and cell cycle, while focal adhesion-PI3K-Akt-mTOR-signaling and integrin-mediated cell adhesion were positively enriched (Fig. 1D). Here, AKT1 is linked to colorectal cancer.