Positively enriched pathways in CtBP2-KD cells included G1 to S cell cycle control, MAPK signaling pathway, cell cycle, DDR, and focal adhesion-PI3K-Akt-mTOR-signaling pathway; negatively enriched pathways included TGF-beta signaling pathway, ErbB signaling pathway, apoptosis, and epithelial to mesenchymal transition in colorectal cancer (Fig. 1E). This evidence concerns the gene CTBP2 and colorectal cancer.