Positively enriched pathways in CtBP1/2-DKD cells included rapamycin (TOR) signaling and apoptosis target; negatively enriched pathways included focal adhesion-PI3K-Akt-mTOR-signaling pathway, tumor suppression activity of SMARCB1, Wnt signaling pathway, photodynamic therapy-induced HIF-1 survival signaling, and glycolysis and gluconeogenesis, and metabolic reprogramming in the colon cancer (Fig. 1E). This evidence concerns the gene AKT1 and colonic neoplasm.