CTBP1 and ovarian serous adenocarcinoma: To explore the impact of CtBPs knockdown in DSBs repair, the SSR 2.0 reporter was used to evaluate the NHEJ/HR pathway shift in shRNA-mediated CtBP1/2 KD serous ovarian cancer cells, which is a genetic encoding sensor that specifically measures the shift of NHEJ or HR pathway by I-SceI-induced DSBs repair [29] (Fig. S3A).