These genetic alternations of CtBP1/2 were summarized, including P308H missense mutation and LYAR fusion in CtBP1, and K434Nfs*33 frameshift deletion and KCNMA1-CtBP2 gained fusion merged in CtBP2 (Table S4), including fusion, amplification and homo deletion, missense mutation, and copy-number alterations, which are primarily distributed in ovarian cancer and ovarian epithelial cancer. Here, KCNMA1 is linked to ovarian carcinoma.