COVID-19 is recently reported to be associated with elevated markers of inflammation, coagulation and endotheliopathy in the liver endothelium driven by IL-6 trans-signaling, which represents a new mechanism of liver injury caused by SARS-CoV-2 infection.34 However, the precise mechanism underlying these features of endothelial dysfunction and COVID-19 is largely unknown. The gene discussed is IL6; the disease is COVID-19.