After adjusting for glutamate treatment and known preoperative non-cardiac confounders age, eGFR, female gender, and obesity, NT-proBNP POD1 was 2.18 times higher in patients with severe PHF than in patients without PHF (adjusted coefficient 0.339, 95%CI 0.134–0.543, p = 0.001; Additional table S5). This evidence concerns the gene NPPB and Obesity.