We did not have data on inflammation but after adjusting for glutamate treatment, age, eGFR, female gender, and obesity we found that NT-proBNP on average was approximately 1.5 times and 2 times higher postoperatively in patients with PHF and severe PHF respectively on POD1 and POD3. This evidence concerns the gene NPPB and obesity due to melanocortin 4 receptor deficiency.