NPPB and obesity due to melanocortin 4 receptor deficiency: After adjusting for glutamate treatment and known preoperative non-cardiac confounders age, eGFR, female gender, and obesity, NT-proBNP POD1 was 1.46 times higher in patients with PHF than in patients without PHF (adjusted coefficient 0.165, 95%CI 0.062–0.269, p = 0.002; Additional table S2).