Recently, studies have demonstrated that tumor necrosis factor-α-induced-protein 3 (TNFAIP3) gene polymorphisms (rs2230926 and rs5029937) are allied with the promoted risk of RA [126], and also revealed that TNFAIP3 expression is significantly lessened in RA patients compared with the healthy controls. This evidence concerns the gene TNFAIP3 and rheumatoid arthritis.