AKT1 and myocardial infarction: Moreover, AKT-MSCs- exosomes considerably enhanced endothelial cell growth and motility, boosted the creation of tube-like construction in vitro, and also improved blood vessel development in vivo possibly mediated by induction of platelet-derived growth factor D (PDGF-D) expression and activation, highlighting the prominent functions of PDGF-D in AKT-MSCs- exosomes -induced angiogenesis in MI models [134].