Furthermore, exosomal miR-122 could modify the expression of insulin-like growth factor receptor 1 (IGF1R), Cyclin G (1) (CCNG1) and prolyl-4-hydroxylase α1 (P4HA1) contributed to the proliferation of and collagen maturation in HSCs in CCl4-induced liver fibrosis models, and thereby could reduce collagen depositions and consequently alleviate liver fibrosis [99]. Here, IGF1R is linked to Hepatic fibrosis.