Based on the univariate analysis data shown in Table 3, the risk factors for a poorer ICC prognosis included the expression of PD-L1 in the tumor, the numbers of CD8-positive TILs and NILs, the TNM stage, and high serum levels of direct bilirubin (DB) and gamma-glutamyl transpeptidase (γ-GT). Here, GGTLC1 is linked to neoplasm.