IL6 and COVID-19: Studies have shown that in males, mutations in X-linked genes (e.g., TLR7) resulting in reduced interferon (IFN) signaling (11), elevated proinflammatory cytokine production (e.g., interleukin-6 [IL-6] and C-reactive protein [CRP]) (2, 12), reduced CD8+ T cell activity (e.g., IFN-γ) (13), and greater antibody responses (i.e., anti-SARS-CoV-2 antigen-specific IgM, IgG, and IgA and neutralizing antibodies) (14) are associated with more severe COVID-19 outcomes than in females.