Recent reports link TRPA1 to the proinflammatory cytokine IL-6 in models of chemotherapy-induced and bone cancer pain,50,97 and in our previous studies, mice with a conditional deletion of the gp130 in Nav1.8 expressing neurons (SNS-gp130−/−) exhibit reduced mechanosensitivity associated with decreased levels of TRPA1 in primary nociceptive afferents.2,54 Therefore, we set out to address the relevance of the IL6/gp130 to TRPA1 axis for neuropathic pain in the murine model of spared nerve injury (SNI). The gene discussed is TRPA1; the disease is bone neoplasm.