ANGPT2 and hepatocellular carcinoma: MMP9, PGF, TGFB1, VEGFA, ANGPT2, CTNNB1, PDCD10, AGGF1, ANGPT1, ITGAV had a higher hazard ratio, and were highly expressed in HCC tissues, indicating that the expression of these genes could promote the secretion of angiogenic factors, and angiogenesis was also accelerated with abnormalities of tumor blood vessels, leading to rapid tumor development and poor prognosis.