According to the survival analyses of a single gene and the coefficient of each gene in the signature, these genes could be roughly divided into two categories, one of which was related to the poor prognosis of HCC (ANGPT1, ITGAV, PDCD10, PGF), and the other was associated with the suppression of HCC (COL18A1, ENG, PON1). The gene discussed is COL18A1; the disease is hepatocellular carcinoma.