Recent studies have shown that HER2 and HER4 are over-expressed in the hippocampus of human AD brains and that degradation of HER2 enhances autophagic flux, causes degradation of amyloid-β, and improves the cognitive functions of APP/presenilin-1 (PS1) mice [41, 42]. The gene discussed is ERBB2; the disease is Alzheimer disease.