As the pathologies of AD, ALS and HC all involve sustained expression of denatured toxic proteins, and as our oncology and virology-based drug combinations stimulate autophagosome formation, ER stress and reduced protein translation and autophagic digestion of proteins, we determined whether our repurposed drug combinations using transformed / tumor cell systems, not neurons, could reduce expression of Tau and APP via autophagy. This evidence concerns the gene APP and Alzheimer disease.