CDH23 expression was positively interacted with LCNL1, CLCN7, GPR153, SLC27A1, CDK18, etc. Otherwise CDH23 expression was negatively related with DDX52, TOP2A, PTPDC1, etc. Further we selected the significantly correlated genes (cor≥0.5) of CDH23 to conduct prognosis analysis in DLBCL via GEPIA database. This evidence concerns the gene TOP2A and diffuse large B-cell lymphoma.