The magnitude of the CIS quantified with the CIS ratio is associated with the neurofibrillary tangle (NFT)-tau stage at autopsy, such that higher Braak NFT stage at autopsy correlates with a lower antemortem CIS ratio in patients with DLB (Graff-Radford et al., 2020). This evidence concerns the gene MAPT and Neurofibrillary tangles.