As another example, scLink identified an edge between EGR1 and NUDT3 in the normal sample (scLink’s correlation =  − 0.48, adjusted P = 0.004) but not in the tumor sample (scLink’s correlation = 0.35), and both genes were reported to have regulatory roles in breast cancer (Figure 5A) [54], [59]. This evidence concerns the gene EGR1 and breast carcinoma.