PDX1 and neoplasm: We investigated the presence of TLSs in 2 widely used murine models of PDAC, the KPC (KrasG12D, p53R172H, Pdx-1-Cre) genetically engineered model of PDAC, and the more cost- and time-effective orthotopic implantation of KPC-derived tumor cell line into immune-competent murine pancreas (referred to as orthotopic) (Figure 2A and B).