MMP2 and ovarian carcinoma: Gong et al. found that up-regulated miR-17 in ovarian cancer cells could decrease the production of activated MMP-2 and inhibit ovarian cancer cell peritoneal metastasis [44].In addition, Jia et al. reported downregulation of TWIST1 decreased cell viability, inhibited migration, and promoted apoptosis of OS cells [45], Sun et al. found miR-143-3p inhibited the proliferation, migration, and invasion of OS cells by targeting FOSL2 [46].