We further analyzed the relationship between ERBB2 expression and tumor infiltrating lymphocytes (TILs) via The Tumor IMmune Estimation Resource (TIMER) algorithm database (https://cistrome.shinyapps.io/timer/) since TILs status played a pivotal role in the progression from esophagitis to Barrett esophagus and EAC [19]. The gene discussed is ERBB2; the disease is esophagitis.