Calnexin is an ER chaperone that has been implicated in cardiomyocyte viability and in ER stress, a prominent clinical feature of cardiovascular disease [29], while ITPR1 mediates the influx and release of intracellular Ca2+ and is regulated by the palmitoylation cascade of ZDHHC16/ZDHHC6 [30, 31]. Here, ZDHHC6 is linked to cardiovascular disorder.