Exposure to homocysteine, a well-documented risk factor for atherosclerosis and stroke [41, 42], in endothelial cells can form the intermediate S-nitroso-homocysteine, a vasodilator implicated in reducing vascular tone and altering arteriole calcium levels [40] Collectively, these associations have identified a novel association with ZDHHC6 and implicate PI3K/Akt signaling in time to stroke and/or vascular event following stroke [43, 44]. The gene discussed is AKT1; the disease is atherosclerosis.