Meanwhile, the KEGG analysis revealed that the PI3K-Akt signaling pathway, focal adhesion, cytokine-cytokine receptor interaction, cGMP-PKG signaling pathway, MAPK signaling pathway, proteoglycans in cancer, vascular smooth muscle contraction, calcium signaling pathway, cell adhesion molecules, and dilated cardiomyopathy were the most frequently enriched pathways (Fig 8B). Here, AKT1 is linked to cancer.