BTK and Decreased circulating immunoglobulin concentration: As per the diagnostic criteria, the patient needs to be a male, who has hypogammaglobulinemia or agammaglobulinemia, <2 percent CD19+ B cells, and either a male family member of maternal lineage who is documented to have agammaglobulinemia and <2 percent CD19+ B cells or a confirmed (by DNA, messenger ribonucleic acid (mRNA), or protein analysis) defect in the BTK gene or Btk expression [6].