LRFN2 and early-onset autosomal dominant Alzheimer disease: A recent proteomic screen on pre-frontal post-mortem tissue also revealed that LRFN2 protein expression was significantly decreased in people with Alzheimer’s disease, Parkinson’s disease with dementia, and dementia with Lewy bodies, further highlighting the importance of LRFN2 for neuronal function (Bereczki et al., 2018).