ACAN and Osteopenia: The possible reason might include that according to the previous studies, lncRNA TUG1 overexpression decreased miR‐195 expression, collagen, and aggrecan, leading to the degradation of chondrocyte extracellular matrix and further bone disorder (pain, osteopenia, fracture), and meanwhile, bone disorder associated with bone marrow infiltration is risk factors for ALL, and therefore, lncRNA TUG1 might be implicated in the initiation and progression of ALL.14, 19