SPP1 and acute lymphoblastic leukemia: The possible reasons might include that (a) according to the existing evidence, lncRNA TUG1 was correlated with the level of osteocalcin and osteopontin, increased systematic inflammation level, and deteriorative bone injury, and therefore, lncRNA TUG1 might promote the susceptibility of CNSL, release of WBC, and increase the occurrence of bone marrow blasts in Ph− ALL patients.14, 15, 20, 21