Suppression of EPAS1 in colon cancer cells (SW480−EPAS1 and Lovo−EPAS1) induced the reduction of colony formation rates significantly when compared to SW480+Scr and Lovo+Scr and non‐transfected SW480wildtype & Lovowildtype control colon cancer cells (Figure 5C,D). Here, EPAS1 is linked to malignant colon neoplasm.