A 39% (n = 5/13) of patients with CRC bearing EPAS1 mutations were grade 3, while 8% (n = 1/12) and 12% (n = 7/57) patients with CRC having EPAS1 mutations were grade 1 or grade 2, respectively (p = 0.04). Here, EPAS1 is linked to colorectal carcinoma.