SH3PXD2A and neoplasm: The protease‐dependent invasion program of tumor cells is mediated by invadopodia, which are F‐actin‐, cortactin‐based cell–matrix contacts that enzymatically degrade and push confining ECM fibers aside to allow cell movement.[17, 18, 19, 20] The scaffolding protein, TKS5, plays a pivotal role in the assembly and surface accumulation of the trans‐membrane matrix metalloproteinase and collagenase, MT1‐MMP, to invadopodia.[20, 21, 22, 23] Here, we investigated the mechanism of ECM degradation under conditions of nutrient scarcity in relation with mTOR signaling.