MTOR and breast cancer: Upon AA starvation, mTORC1 is inactivated inducing autophagy, cellular catabolism, and translation shut down.[14] Dysregulation of the PI3K/Akt/mTOR signaling pathway is linked with breast cancer initiation and progression and regional heterogeneity in immunohistochemical profiles of phosphorylated (p)‐mTOR and its downstream signaling effectors, pS6K, and p4E‐BP1 have been described in relation with metabolic alterations.[15, 16]