We adopted Mahalanobis distance (MD) analysis to represent similarities between random tumor samples within a given patient as described previously.[32] MD values were calculated based on two gene lists, including a 35‐gene list for immune cell markers (CD8+ T cells, CD4+ T cells, regulatory T cells (Tregs), B cells, macrophages, neutrophils, and dendritic cells (DCs)), and a 61‐gene list for immune‐related functional markers (antigen presentation, cell adhesion, co‐inhibitor, co‐stimulator, ligand, cytokine, and exhausted receptor) (Figure S3A,B and Tables S7, S8, Supporting Information). This evidence concerns the gene CD8A and neoplasm.