CD4 and neoplasm: We adopted Mahalanobis distance (MD) analysis to represent similarities between random tumor samples within a given patient as described previously.[32] MD values were calculated based on two gene lists, including a 35‐gene list for immune cell markers (CD8+ T cells, CD4+ T cells, regulatory T cells (Tregs), B cells, macrophages, neutrophils, and dendritic cells (DCs)), and a 61‐gene list for immune‐related functional markers (antigen presentation, cell adhesion, co‐inhibitor, co‐stimulator, ligand, cytokine, and exhausted receptor) (Figure S3A,B and Tables S7, S8, Supporting Information).