To further explore the relationship between tumor cells and T cells, we analyzed the cell‐cell interaction network (Figure 7M and Table S17, Supporting Information).[45] The enrichment of both immune‐activated (HLA‐E_KLRC1, IFNG_IFNR, NKG2A_HLA‐E, TNFSF14_LTBR, and TNFSF14_TNFRSF14) and immune‐inhibitory (PDCD1_CD274, PVR_TIGIT, LGALS9_HAVCR2, CTLA4_CD80, and CDH1_KLRG1) interactions in the IDH‐NO group corroborated our previous notion that CD8+ T cells exhibited an activation‐coupled exhaustion feature. Here, HLA-E is linked to neoplasm.