Meanwhile, the expression of inflammatory factors was decreased in peripheral blood and cerebrospinal fluid of mice, and the levels of IL‐6, IL‐1β and TNF‐α in cerebrospinal fluid were especially significantly lower than those of AD mice, which was because miRNA‐22 endocytosis can inhibit GSDMD activation to further improve the release of inflammatory factors. This evidence concerns the gene IL6 and Alzheimer disease.