Moreover, our data provide a rationale for combinatorial approaches, for example, the addition of PAG may increase the vulnerability to oxidative damage caused by radiation.7 Recently, the combination of radiotherapy with a glutaminase inhibitor was shown to increase mouse survival.45 The anti-tumor effects of CSE inhibition may be potentiated by a dietary restriction of cysteine to simultaneously interfere with exogenous and endogenous cysteine supply. The gene discussed is GLS; the disease is neoplasm.