We previously identified metabolic aberrations in phospholipid, energy and oxidative stress regulation in IDHm gliomas.10 Notably, despite a drop in the NADPH/NADP+ ratio, GSH levels were barely affected in IDH1m tumors, while enzymes related to cysteine metabolism and de novo GSH production such as cystathionine-β-synthase (CBS) and Glutamate-cysteine ligase catalytic subunit (GCLC) showed increased gene expression, suggesting that de novo GSH synthesis might be active in these tumors.10 This evidence concerns the gene GCLC and central nervous system cancer.