To address this in a model amenable to experimental manipulation, we turned to patient-derived glioma stem-like cells (GSCs) carrying the endogenous IDH1 mutation (NCH1681, NCH551b, NCH612) and control cells of IDHwt GBM (NCH644, NCH601, NCH421k) (Supplementary Figure S1a). Here, IDH1 is linked to glioma.