The estimated incidence of moderate/severe OHSS was 2.14% (95% CI 1.156–5.36) for infertile women undergoing ovarian stimulation with a GnRH antagonist protocol and 6.43% (95% CI 2.75–11.33) for women with a GnRH agonists protocol. Here, GNRH1 is linked to ovarian hyperstimulation syndrome.