The incidence of OHSS was reduced significantly with the availability of GnRH antagonists (Al-Inany et al., 2011) and was almost eliminated with the replacement of hCG with GnRH agonist and freezing all embryos in high-risk patients (Tarlatzis and Bosdou 2017; Vlaisavljevic et al., 2017). The gene discussed is GNRH1; the disease is ovarian hyperstimulation syndrome.