For example, Xiong et al. indicated that HULC positively regulated ubiquitin-specific peptidase 22 (USP22) expression to stabilize silent information regulator 1 (Sirt1) protein and induce protective autophagy, thereby inhibiting the sensitivity of hepatocellular carcinoma cells to oxaliplatin, 5-fluorouracil, and pirarubicin (THP) treatment [17]. The gene discussed is USP22; the disease is hepatocellular carcinoma.