It was worth noting that some genes were involved in the process of neuronal activity, such as CBR3, FZD6, NEFL, PROX2, PRDM6, S100B, and GZMA. NEFL was found to be involved in amyotrophic lateral sclerosis- (ALS-) related signaling pathways at the same time. This evidence concerns the gene S100B and amyotrophic lateral sclerosis.