Echocardiography with longitudinal strain and cardiac magnetic resonance imaging may demonstrate findings consistent with cardiac amyloidosis and improve prognostication, while bone scintigraphy with technetium-based agent [pyrophosphate (PYP), 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD), and hydroxymethylene diphosphonate (HMDP)] are highly specific for transthyretin cardiac amyloidosis in the setting of negative blood and urine testing for a plasma cell disorder (2). This evidence concerns the gene TTR and cardiac amyloidosis.