Patients with moderate MR had lower LVEF (39.53 ± 6.94% vs. 42.51 ± 6.53%, P < 0.01) and higher levels of NT-proBNP (3,518.64 ± 3,454.20 vs. 2,239.40 ± 3,087.90, and P < 0.01) as compared to those with no-mild MR. The gene discussed is NPPB; the disease is miotic rate.