According to MoA analysis, nine mechanisms of actions (acetylcholine receptor agonist, serotonin receptor agonist, calcium channel blocker, progesterone receptor agonist, GABA receptor antagonist, dopamine receptor antagonist, calmodulin antagonist, retinoid receptor agonist and PARP inhibitor) shared the above small molecule inhibitors, indicating that nine small molecule inhibitors might suppress ccRCC progression through mediating these mechanisms of actions. The gene discussed is PGR; the disease is nonpapillary renal cell carcinoma.