NLRP3-associated autoinflammatory disease (NLRP3-AID) (formerly called cryopyrin-associated periodic syndrome, CAPS), an autosomal dominantly inherited SAID, encompasses a group of disorders with overlapping phenotypes including, in order of increasing severity, familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), and chronic infantile neurological cutaneous articular (CINCA) syndrome. Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.