Previously, others have shown that combining adiponectin with homeostatic model assessment for insulin resistance and type IV collagen 7S increased the assay sensitivity from 68 to 94% in early-stage NASH prediction (38), while combining adiponectin, resistin, and cleaved cytokeratin-18 predicted NASH with an AUROC of 0.90 (39). This evidence concerns the gene RETN and metabolic dysfunction-associated steatohepatitis.