In this cohort, serum adiponectin was only able to distinguish NAFL vs. NASH when NAFLD patients homozygous for PNPLA3 wild-type allele c.444C were considered, even though with a suboptimal performance (AUROC = 0.63; p < 0.05) (Figure 3B). Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.