In the discovery cohort, adiponectin was similar among men and women (6.55 ± 0.98 vs. 7.79 ± 1.04 μg/ml) and significantly lower in NASH vs. NAFL (non-obese controls: 8.51 ± 1.94 μg/ml; NAFL: 9.23 ± 0.85 μg/ml; NASH: 4.45 ± 0.58 μg/ml; p < 0.01) (Figure 3A). This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatohepatitis.