In the validation cohort, adiponectin was lower in men (4.4 ± 0.32 vs. 6.07 ± 0.29 μg/ml, p < 0.0001) and, although not significant, were lower in NASH (4.94 ± 0.27 μg/ml) vs. both non-obese (6.21 ± 0.97 μg/ml) and obese (6.56 ± 0.93 μg/ml) controls or NAFL (6.22 ± 0.45 μg/ml). The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.